Publications

1. eLife Digest. Defective enzyme weakens cell wall. 2020.Allison Hillary Williams et al. . View Publication.

2. Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis. Elife. 2020 Feb 05; 9.Williams AH, Wheeler R, Deghmane AE, Santecchia I, Schaub RE, Hicham S, Moya Nilges M, Malosse C, Chamot-Rooke J, Haouz A, Dillard JP, Robins WP, Taha MK, Gomperts Boneca I.  PMID: 32022687.

3. The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation. Nat Commun. 2019 07 08; 10(1):3005.Williams AH, Redzej A, Rolhion N, Costa TRD, Rifflet A, Waksman G, Cossart P.  PMID: 31285450.

4. Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase. Sci Rep. 2019 03 08; 9(1):3947.Dangkulwanich M, Raetz CRH, Williams AH.  PMID: 30850651.

5. Author Correction: N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes. Nat Microbiol. 2018 Aug; 3(8):962.Impens F, Rolhion N, Radoshevich L, Bécavin C, Duval M, Mellin J, García Del Portillo F, Pucciarelli MG, Williams AH, Cossart P.  PMID: 29941881.

6. A step-by-step in crystallo guide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase. J Biol Chem. 2018 04 20; 293(16):6000-6010.Williams AH, Wheeler R, Rateau L, Malosse C, Chamot-Rooke J, Haouz A, Taha MK, Boneca IG.  PMID: 29483188.

7. Bulgecin A: The Key to a Broad-Spectrum Inhibitor  That Targets Lytic Transglycosylases. Antibiotics (Basel). 2017 Feb 22; 6(1).Williams AH, Wheeler R, Thiriau C, Haouz A, Taha MK, Boneca IG.  PMID: 28241458.

8. N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes. Nat Microbiol. 2017 Feb 13; 2:17005.Impens F, Rolhion N, Radoshevich L, Bécavin C, Duval M, Mellin J, García Del Portillo F, Pucciarelli MG, Williams AH, Cossart P.  PMID: 28191904.

9. Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members. Acta Crystallogr D Biol Crystallogr. 2014 Oct; 70(Pt 10):2631-9.Williams AH, Veyrier FJ, Bonis M, Michaud Y, Raynal B, Taha MK, White SW, Haouz A, Boneca IG.  PMID: 25286847.

10. The dynamics of peptidoglycan structure and function: conference report on the 3rd Great Wall Symposium. Res Microbiol. 2014 Jan; 165(1):60-7.Williams AH, Boneca IG, Burrows LL, Bugg TD.  PMID: 24239960.

11. De-O-acetylation of peptidoglycan regulates glycan chain extension and affects in vivo survival of Neisseria meningitidis. Mol Microbiol. 2013 Mar; 87(5):1100-12.Veyrier FJ, Williams AH, Mesnage S, Schmitt C, Taha MK, Boneca IG.  PMID: 23373517.

12. Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Mol Cell. 2011 Nov 04; 44(3):451-61.Taherbhoy AM, Tait SW, Kaiser SE, Williams AH, Deng A, Nourse A, Hammel M, Kurinov I, Rock CO, Green DR, Schulman BA.  PMID: 22055190.

13. Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA. Biochemistry. 2009 Jul 07; 48(26):6191-201.Robins LI, Williams AH, Raetz CR.  PMID: 19456129.

14. Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13543-50.Williams AH, Raetz CR.  PMID: 17698807.

15. Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):10877-82.Williams AH, Immormino RM, Gewirth DT, Raetz CR.  PMID: 16835299.

16. Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3″-hydroxyl group. J Biol Chem. 2004 Jun 11; 279(24):25411-9.Sweet CR, Williams AH, Karbarz MJ, Werts C, Kalb SR, Cotter RJ, Raetz CR.  PMID: 15044493.