The existence of all living entities is sustained by a diverse array of molecular nanomachines that engage in vital cellular processes, such as the creation of new nucleic acids and proteins. These molecular entities also undertake crucial roles in responding to detrimental and potentially fatal environmental alterations by triggering or facilitating survival pathways. Several of these macromolecular machines have been meticulously analyzed, revealing detailed atomic structures that explain their molecular functions. However, due to their complexity, studies often investigate these protein macromolecular machines in isolation, which significantly contrasts with their natural molecular habitats.

We are navigating an era where understanding the connections between diverse cellular processes is a pivotal area of scientific inquiry. My research endeavor is committed to unraveling the molecular foundations that dictate the functions of intricate, yet structurally undefined, protein macromolecular machines. In the Williams Lab, we use X-ray crystallography, cryo-electron microscopy (cryo-EM) single molecule reconstruction, biochemical, genetic, and in vivo studies to probe fundamental aspects of bacterial physiology.

Our multifaceted approach stands to significantly influence drug development, serving as a cornerstone in the fight against antibiotic drug resistance. By delving deeper into the intricacies of these molecular nanomachines, we endeavor to enrich our understanding of their critical roles in sustaining life and adapting to environmental challenges, thereby advancing our grasp of cellular processes, and paving the way for innovations in medicine. This holistic exploration forms the essence of our mission, as we relentlessly pursue groundbreaking advancements in scientific understanding and therapeutic solutions.